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KMID : 0616120120430030217
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 3 p.217 ~ p.223
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Inhibitory Effect of Artemisinic Acid Isolated from Artemisia Annua L on the MDC in HaCaT Keratinocytes
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Kang Gyeoung-Jin
Kang Na-Jin
Han Sang-Chul
Koo Dong-Hwan
Kim Young-Soo
Lee Jin-Hyuck
Kim Sang-Chul
Park Deok-Hoon
Lee Jong-Sung
Kang Hee-Kyoung
Yoo Eun-Sook
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Abstract
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In the present study, we investigated anti-inflammatory activity of artemisinic acid in HaCaT cells and RAW264.7 cells. Artemisinic acid showed inhibitory activity on macrophage-derived chemokines (MDC) expression, a factor related with atopic dermatitis (AD), in interferon (IFN)- and tumor necrosis factor (TNF)--stimulated HaCaT cells. In the study on action mechanism, pretreated artemisinic acid reduced the phosphorylation of STAT1 and p38 and the degradation of by IFN- and TNF- stimulations. However, artemisinic acid didn’t show the inhibitory activity on LPS-induced inflammatory mediators (NO, , IL-6) in RAW264.7 cell. These results indicate that artemisinic acid inhibits IFN- and TNF--induced MDC expression through inhibition of signal factors, STAT1, NF-, and p38, in HaCaT keratinocytes.
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KEYWORD
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Artemisinic acid, Inflammation, MDC/CCL22, HaCaT keratinocyte, RAW264.7, Macrophages
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